Synthesis and evaluation of aborted and extended CC-1065 functional analogs:(+)-and (-)-CPI-PDE-I1,(+)-and (-)-CPI-CDPI1, and (.+-.)-,(+)-, and (-)-CPI-CDPI3. …

…, H Zarrinmayeh, PA Kitos, SC Thompson

Index: Boger; Coleman; Invergo; Sakya; Ishizaki; Munk; Zarrinmayeh; Kitos; Thompson Journal of the American Chemical Society, 1990 ,  vol. 112,  # 12  p. 4623 - 4632

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Citation Number: 100

Abstract

Abstract: Full details of the incorporation of (&)-(lR*)-8,(-)-(lS)-8, and (+)-(1R)-8 into the total syntheses of the aborted and extended CC-1065 functional analogues (+)-and (-)-CPI-PDE- II [(+)-and (-)-l],(+)-and (-)-CPI-CDPIl [(+)-and (-)-31, and (&)-,(+)-, and (-)-CPI-CDPI,[(&)-,(+)-, and (-)-51 are described. Comparative DNA binding studies of the agents versus (+)-N-BOC- CPI (a),(+)-N-acetyl-CPI (7),(+)-CC-1065 (2), and (+)-/(-) CPI-CDP12 (4) are presented in ...