The Journal of Organic Chemistry

Efficient synthesis of furochromone and furocoumarin natural products (khellin, pimpinellin, isophellopterin) by thermal rearrangement of 4-furyl-4- …

MW Reed, HW Moore

Index: Reed, Michael W.; Moore, Harold W. Journal of Organic Chemistry, 1988 ,  vol. 53,  # 8  p. 4166 - 4171

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Citation Number: 32

Abstract

Background Most recent synthetic efforts toward khellin have been directed at its benzofuran precursor khellinone (9P since it can be converted to khellin in 85% yield by a Claisen-like condensation with ethyl acetate, followed by acid-catalyzed cyclization and dehydration. & Khellinone has the further advantage that it can be converted to khellin analogues when substituted acetates are used in the condensationa2 Historically, construction of the fully ...