Tetrahedron Letters

Enantiospecific total synthesis of pseudomonic acids from arabinose

GWJ Fleet, MJ Gough, TKM Shing

Index: Fleet, G. W. J.; Gough, M. J.; Shing, T. K. M. Tetrahedron Letters, 1983 ,  vol. 24,  # 34  p. 3661 - 3664

Full Text: HTML

Citation Number: 22

Abstract

Pseudomonic acids A (I) and C (2) are members of a novel class of compounds with antibacterial and antimycoplasmal activity.' The first reported synthesis of racemic pseudomonic acid C involved a key step of coupling the racemic form of the pyranose aldehyde (3) with the ylid derived from the racemic form of the phosphonium salt (4)(Scheme 1). 2 Subsequent approaches to racemic3 pseudomonic acids have been directed ...