The Alkylation of 3, 5-Dimethylisoxazole

C Kashima, S Tobe, N Sugiyama…

Index: Kashima,C. et al. Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 310 - 313

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Citation Number: 33

Abstract

3, 5-Dimethylisoxazole (1) was alkylated with sodium amide in liquid ammonia to give 3- methyl-5-alkylisoxazoles. By di-and tri-alkylation reactions using excess sodium amide, isoxazoles having secondary and tertiary alkyl groups at 5-position could be obtained. The hydrogenolysis and hydrolysis of these isoxazoles were also studied.