Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives Are Potent and Selective. sigma. 1 Ligands

SN Calderon, S Izenwasser, B Heller…

Index: Calderon, Silvia N.; Izenwasser, Sari; Heller, Brett; Gutkind, J. Silvio; Mattson, Mariena V.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2285 - 2291

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Citation Number: 21

Abstract

Carbetapentane (1, 2424 diethylamino) ethoxy] ethyl l-phenyl-l-cyclopentanecarboxylate) binds with high affinity to 0 sites and is a potent antitussive, anticonvulsant, and spasmolytic agent. However, carbetapentane interacts at muscarinic binding sites as well, and it is not clear whether either of these receptor systems is involved in the mechanism ($ of action (s) of this drug. In an attempt to determine whether these psychoactivities can be attributed to ...