Study for the determination of the absolute configuration of fluoromethylated secondary alcohols by the modified Mosher method

L Xiao, T Yamazaki, T Kitazume, T Yonezawa…

Index: Xiao, Ling; Yamazaki, Takashi; Kitazume, Tomoya; Yonezawa, Tetsuo; Sakamoto, Yoshitake; Nogawa, Kouji Journal of Fluorine Chemistry, 1997 ,  vol. 84,  # 1  p. 19 - 23

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Citation Number: 14

Abstract

Application of the modified Mosher method using high-field FT 1H NMR to the 2-methoxy-2- phenyl-2-trifluoromethyl acetic acid (MTPA) derivatives of fluorinated secondary alcohols indicates that this method may be generally used to determine the absolute configurations of these materials.