Synthesis of N-acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis

G Wasonga, Y Tatara, I Kakizaki…

Index: Wasonga, Gilbert; Tatara, Yota; Kakizaki, Ikuko; Huang, Xuefei Journal of Carbohydrate Chemistry, 2013 ,  vol. 32,  # 5-6  p. 392 - 409

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Citation Number: 3

Abstract

Elevated hyaluronan expression is a hallmark of many types of cancer. Therefore, inhibition of hyaluronan biosynthesis can potentially slow the growth of tumor cells. Herein, we explore a chain termination strategy to reduce hyaluronan synthesis by tumor cells. Several analogs of glucosamine were prepared, which contained modifications at the C-3 positions. These analogs can possibly cap the nonreducing end of a growing hyaluronan chain, thus ...