Novel hydroxyphenylurea dual inhibitor against acyl-CoA: cholesterol acyltransferase (ACAT) and low density lipoprotein (LDL) oxidation as antiatherosclerotic agent

…, M Yasuhara, K Saito, T Suzuki, H Ohmizu…

Index: Nakao, Kazuya; Kubota, Hitoshi; Yasuhara, Mikiko; Saito, Keiko; Suzuki, Toshikazu; Ohmizu, Hiroshi; Shimizu, Ryo Bioorganic and Medicinal Chemistry, 2001 ,  vol. 9,  # 4  p. 853 - 861

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Citation Number: 7

Abstract

Novel hydroxyphenylurea derivatives were synthesized and their inhibitory potency evaluated against acyl-CoA: cholesterol acyltransferase (ACAT). Quantitative structure– activity relationship analysis revealed that their ACAT inhibitory activities were controlled by the hydrophobicity of the whole molecule, the substitution pattern of urea moiety, and the existence of carboxylic acid. The derivatives with strong activities inhibited foam cell ...