Novel enantioselective synthesis of α-methylthreonines and α, β-dimethylcysteines

H Shao, JK Rueter, M Goodman

Index: Shao, Hui; Rueter, Jaimie K.; Goodman, Murray Journal of Organic Chemistry, 1998 ,  vol. 63,  # 15  p. 5240 - 5244

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Citation Number: 43

Abstract

Recently, the incorporation of conformationally constrained amino acids into biologically active peptides has emerged as an important route to prepare peptide-based drug molecules. 1 Results have clearly demonstrated that such a strategy can effectively optimize the populations of possible conformations to assist conformational analysis, identify the required pharmacophoric groups to generate potent and receptor-specific ligands, and ...