Tetrahedron Letters

Enzymatic synthesis of (S)-glutaric acid monoesters aided by molecular docking

B Wang, J Liu, X Tang, C Cheng, J Gu, L Dai, H Yu

Index: Wang, Bo; Liu, Ji; Tang, Xiaoling; Cheng, Cheng; Gu, Jiali; Dai, Liyan; Yu, Hongwei Tetrahedron Letters, 2010 , vol. 51, # 2 p. 309 - 312

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Citation Number: 14

Abstract

An efficient enzymatic method for the synthesis of (S)-3-substituted glutaric acid monoesters which was aided by molecular docking has been described. The reaction was proceeded under mild conditions, and the desired products were afforded with up to 98% ee in the yield of 93%. The results demonstrate that molecular docking is efficient to facilitate selection of substrates in enzymatic reaction.