Nitrile Alkylations through Sulfinyl–Metal Exchange

D Nath, FF Fleming

Index: Nath, Dinesh; Fleming, Fraser F. Angewandte Chemie - International Edition, 2011 , vol. 50, # 49 p. 11790 - 11793

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Citation Number: 10

Abstract

Nitriles play pivotal roles in a diverse range of pharmaceuticals.[1] The nitrile pharmacophore often engages in key hydrogen bonding, as in the blockbuster drug anastrazole (1),[2] in other cases a covalent attachment occurs, as in the anti-diabetic vildagliptin (2, Scheme 1).[3] Syntheses of many nitrile-containing pharmaceuticals, particularly of those bearing quaternary centers, such as anastrazole [1] and the ...