An Efficient Synthetic Route to Novel 3-Alkyl-and 3-Aryl-4-iodophenols

GJ Hermann, MC Annis, PD Edwards, M Corrales…

Index: Hermann, Gesine J.; Annis, Michael C.; Edwards, Peter D.; Corrales, Marta; Diaz, Lucia; Goodnow, Robert A. Synthesis, 2008 , # 2 p. 221 - 224

Full Text: HTML

Citation Number: 0

Abstract

As part of an ongoing project it was necessary to access a series of novel 4-arylphenols containing sterically demanding functionality at the 3-position; in particular phenols with isopropyl, tert-butyl, and phenyl groups were of interest for our work. A viable approach to these compounds via palladium-catalysed coupling of the 3-alkyl- and 3-aryl-4-halophenols 1 (Figure [1] ) was proposed. However, literature searches revealed a paucity of information regarding the ...