Helvetica chimica acta

7??Deazapurine Oligodeoxyribonucleotides: The effects of 7??deaza??8??methylguanine on dna structure and stability

F Seela, Y Chen, C Mittelbach

Index: Seela, Frank; Chen, Yaoming; Mittelbach, Cathrin Helvetica Chimica Acta, 1998 , vol. 81, # 3 p. 570 - 583

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Citation Number: 16

Abstract

Abstract Oligodeoxyribonucleotides containing 7-deaza-2′-deoxy-8-methylguanosine (m 8 c 7 G d; 2b) were prepared. For this purpose, the phosphonate 3a and the phosphoramidite 3b were synthesized and employed in solidphase oligodeoxyribonucleotide synthesis. The structures and the thermodynamic data of duplex formation of oligodeoxyribonucleotides containing 2b were investigated by temperature-dependent CD and UV spectra and ...