Tetrahedron Letters

Synthesis and characterization of flavin-tethered peptide nucleic acid

H Ikeda, K Yoshida, M Ozeki, I Saito

Index: Ikeda, Hisafumi; Yoshida, Kohzo; Ozeki, Makoto; Saito, Isao Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2529 - 2531

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Citation Number: 20

Abstract

We synthesized flavin-containing PNA monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA–DNA hybrids.