Helvetica Chimica Acta

Eine einfache Methode zur Herstellung von Benzoxazolen

Z Seha, CD Weis

Index: Seha, Zdenek; Weis, Claus D Helvetica Chimica Acta, 1980 , vol. 63, # 2 p. 413 - 419

Full Text: HTML

Citation Number: 13

Abstract

Summary The preparation of benzoxazoles by a facile one-pot reaction is reported. The reaction of carboxylic acids with 2-chloro-N-methyl-A*-pyrrolinium chloride in an excess of N- methyl-2-pyrrolidone afforded carboxylic acid chlorides which were converted subsequently to their 2-hydroxyanilides by addition of 2-aminophenols. Cyclization of the 2-hydroxy- anilides at elevated temperatures furnished the benzoxazoles in high yield and purity.