One??Pot Synthesis of Polyfunctionalized 4H??Chromenes and Dihydrocoumarins Based on Copper (II) Bromide??Catalyzed C C Coupling of Benzylic Alcohols with …

D Liang, M Wang, B Bekturhun…

Index: Liang, Deqiang; Wang, Mang; Bekturhun, Bahargul; Xiong, Binbin; Liu, Qun Advanced Synthesis and Catalysis, 2010 , vol. 352, # 10 p. 1593 - 1599

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Citation Number: 44

Abstract

Abstract The synthesis of polyfunctionalized 4H-chromenes 3 and dihydrocoumarins 4 has been developed from the same substrates. Catalyzed by copper (II) bromide (0.3 equiv.), the reactions of the easily available ketene dithioacetals 1 with 2-(hydroxymethyl) phenols 2 lead to 4H-chromenes 3 in high to excellent yields in dichloromethane solvent, whereas, 3, 4- trans-disubstituted dihydrocoumarins 4 are obtained in high yields with high ...