Synthesis and biological evaluation of S-adenosyl-1, 12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase

PM Woster, AY Black, KJ Duff, JK Coward…

Index: Woster, Patrick M.; Black, Alison Y.; Duff, Keith J.; Coward, James K.; Pegg, Anthony E. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1300 - 1307

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Citation Number: 33

Abstract

DATAD), in which critical portions of the nucleophilic aminopropyl acceptor are covalently linked to critical portions of the electrophilic aminopropyl donor to form a potent and specific inhibitor of spermine synthase. In addition, the corresponding desamino analogue which was designed to lack activity against spermine synthase on the basis of substrate structure- activity data has been synthesized as a control. Preliminary biological results demonstrate ...