Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles

…, P Arsenyan, I Shestakova, I Domracheva…

Index: Lukevics, Edmunds; Arsenyan, Pavel; Shestakova, Irina; Domracheva, Ilona; Nesterova, Alena; Pudova, Olga European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 507 - 515

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Citation Number: 80

Abstract

The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl, propargyl and benzyl chlorides and bromides leads to the formation of benzimidazolinium salts. The interaction of N-monosubstituted benzimidazoles with various salts (CuCl2, ZnCl2, CoCl2, PdCl2 and AgNO3) yielded stable solid complexes. Potential cytotoxic activity of synthesised benzimidazolinium salts and benzimidazole metal complexes was tested in ...