Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor

D Heckmann, A Meyer, L Marinelli…

Index: Heckmann, Dominik; Meyer, Axel; Marinelli, Luciana; Zahn, Grit; Stragies, Roland; Kessler, Horst Angewandte Chemie - International Edition, 2007 , vol. 46, # 19 p. 3571 - 3574

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Citation Number: 72

Abstract

Rational drug design relies on an iterative procedure of initial protein–structure determination, followed by the design, chemical synthesis, and subsequent biological evaluations of specific compounds. However, there is still a large gap between known protein sequences and 3D structures. To date, the most successful theoretical approach to bridge this gap is homology modeling. It is possible to construct an approximate 3D model ...