Synthesis of 3-Indolylpyrroles via Base-Mediated Cycloaddition of TOSMIC with Activated Indole-2/3-vinylenes

…, GG Rajeshwaran, AK Mohanakrishnan

Index: Balamurugan, Ramalingam; Sureshbabu, Radhakrishnan; Rajeshwaran, Ganesan Gobi; Mohanakrishnan, Arasambattu K. Synthetic Communications, 2009 , vol. 39, # 3 p. 531 - 543

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Citation Number: 7

Abstract

The tosylmethylisocyanide (TOSMIC) reagent introduced by van Leusen et al. [ 1 1. van Leusen , AM ; Siderius , H. ; Hoogenboom , BE ; van Leusen , D. A new and simple synthesis of the pyrrole ring system from Michael acceptors and tosylmethylisocyanides . Tetrahedron Lett. 1972 , 52 , 5337 – 5340 . [CrossRef] View all references ] has found widespread application in organic synthesis. Of these, the synthesis of five-member heterocycles using TOSMIC is most ...