The Journal of Organic Chemistry

Remote enzyme-coupled amine release

FM Menger, M Ladika

Index: Menger, F. M.; Ladika, M. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3006 - 3007

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Citation Number: 24

Abstract

Summary: A remote enzyme-coupled amine release system has been developed in which biochemical and chemical" demasking" processes are sequentially linked via an enforced 1, 3-diaxial disposition. Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine. The