Synthesis of 4??aminoquinoline??1, 2, 3??triazole and 4??aminoquinoline??1, 2, 3??triazole??1, 3, 5??triazine Hybrids as Potential Antimalarial Agents

S Manohar, SI Khan, DS Rawat

Index: Manohar, Sunny; Khan, Shabana I.; Rawat, Diwan S. Chemical Biology and Drug Design, 2011 , vol. 78, # 1 p. 124 - 136

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Citation Number: 49

Abstract

We report herein synthesis of a series of 4-aminoquinoline-1, 2, 3-triazole and 4- aminoquinoline-1, 2, 3-triazole-1, 3, 5-triazine hybrids and evaluate their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure–activity relationship of substituted 4-aminoquinoline–based hybrids, 34 structurally diverse compounds were synthesized and tested against D6 and W2 strains of P. falciparum. ...