Benzyne reaction. IX. Benzyne reaction of o-halobenzenes with acetonitrile or phenylacetonitrile in organic solvents

T Kametani, K Kigasawa, M Hiiragi…

Index: Kametani,T. et al. Journal of Organic Chemistry, 1971 , vol. 36, # 2 p. 327 - 330

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Citation Number: 7

Abstract

T, he benzyne reaction of a number of ortho-substituted halobenzenes with acetonitrile or phenylacetonitrile was carried out, in various organic solvents together with the appropriate amines in the presence of sodium amide, to give the desired meta-substituted phenylacetonitriles together with meta-substituted amino compounds. When o-chloro-and o- methylhalobenzene were used in this reaction, a mixture of the corresponding 1, 3-and 1, ...