Efficient and Convenient Synthesis of 1, 4-Benzoxazines, 1, 4-Benzothiazines, Spiro-1, 4-benzoxazines, and Spiro-1, 4-benzothiazines

SL Shastri, BM Chougala, MV Kulkarni…

Index: Shastri, Samundeeswari L.; Chougala, Bahubali M.; Kulkarni, Manohar V.; Shastri, Lokesh A. Synthetic Communications, 2013 , vol. 43, # 18 p. 2464 - 2474

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Abstract

An efficient, convenient synthesis of 1,4-benzoxazines, 1,4-benzothiazines, spiro-1,4-benzoxazines , and spiro-1,4-benzothiazines derivatives was accomplished in good yields via the novel intramolecular cyclization mediated by mild base K 2 CO 3 in ethanol solvent. A variety of substrates can participate in the process with good yields, making this methodology have broad applicability. All the structures of synthesized compound have been confirmed by spectral analysis.