Asymmetric synthesis of β-amino acid derivatives via catalytic conjugate addition of hydrazoic acid to unsaturated imides

JK Myers, EN Jacobsen

Index: Myers, Jason K.; Jacobsen, Eric N. Journal of the American Chemical Society, 1999 , vol. 121, # 38 p. 8959 - 8960

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Citation Number: 240

Abstract

Interest in synthetic routes to β-amino acids can be traced to the presence of these building blocks in a variety of biologicallyinteresting natural products, 1 and to the recent revelation that derived peptides show well-defined secondary structures. 2 While several methods for the construction of enantiomerically enriched β-amino acid derivatives have been developed utilizing either chiral substrates or chiral auxiliaries, 1a, 3 the enantioselective ...