Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas

…, MJ Kim, DS Park, H Yu, GR Tian, TS Jeong…

Index: Xu, Ming-Zhe; Lee, Woo Song; Kim, Mi Jeong; Park, Doo-Sang; Yu, Hana; Tian, Guan-Rong; Jeong, Tae-Sook; Park, Ho-Yong Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4277 - 4280

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Citation Number: 18

Abstract

Unsaturated fatty acid amides, 9 (Z)-octadecenamide (2) and 9 (Z), 12 (Z)- octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC50 values of 170, 85, and 63μM for 2 ...