Tetrahedron letters

Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

AM Piggott, P Karuso

Index: Piggott, Andrew M.; Karuso, Peter Tetrahedron Letters, 2005 , vol. 46, # 47 p. 8241 - 8244

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Citation Number: 33

Abstract

Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.