Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

…, M Donghi, M Ferrara, JIM Hernando, M Pompei…

Index: Malancona, Savina; Donghi, Monica; Ferrara, Marco; Martin Hernando, Jose I.; Pompei, Marco; Pesci, Silvia; Ontoria, Jesus M.; Koch, Uwe; Rowley, Michael; Summa, Vincenzo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 8 p. 2836 - 2848

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Citation Number: 17

Abstract

Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo [de] isoquinoline-1, 3 (2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved ...