ChemBioChem

Rational Design, Synthesis and Biological Evaluation of Modular Fluorogenic Substrates with High Affinity and Selectivity for PTP1B

S Sanchini, F Perruccio, G Piizzi

Index: Sanchini, Silvano; Perruccio, Francesca; Piizzi, Grazia ChemBioChem, 2014 , vol. 15, # 7 p. 961 - 976

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Citation Number: 2

Abstract

Abstract Protein-tyrosine phosphatase 1B (PTP1B) is a key regulatory enzyme in several signal transduction pathways, and its upregulation has been associated with type-2 diabetes, obesity and cancer. Selective determination of the functional significance of PTP1B remains a major challenge because the activity of this crucial enzyme is currently evaluated through the use of fluorescent probes that lack selectivity and are limited to ...