Synthesis of O2-and N3-(2-Phosphonomethoxy) ethyl Derivatives of 6-Phenyl-and 6-Pyridinyl-5-azacytosine

…, M Dracinsky, M Krecmerova, J Balzarini, G Andrei…

Index: Otmar, Miroslav; Dracinsky, Martin; Jan Balzarini, Marcela Krecmerovaa; Andrei, Graciela; Snoeck, Robert Heterocycles, 2011 , vol. 83, # 4 p. 797 - 813

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Citation Number: 2

Abstract

Abstract–A series of hydrolytically stable O2-and N3-(2-phosphonomethoxy)-ethyl (PME) derivatives of 6-phenyl, pyridin-2,-3 and-4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy) methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1, 3, 5- triazine-2, 4-diamine (13d) which exhibited slight activity against feline herpesvirus in ...