… of the complement system. 1. Synthesis and biological activity of 5, 5', 5"-[1, 3, 6-naphthalenetriyltris (sulfonylimino)] tris [1, 3-benzenedisulfonate] hexasodium salt

RB Conrow, N Bauman, JA Brockman…

Index: Conrow, R. B.; Bauman, N.; Brockman, J. A.; Bernstein, S. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 240 - 242

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Citation Number: 10

Abstract

I11 previously reported inhibitors, I and suramin sodium'(III). Thus, IIb is approximately 30 times more active than ei-ther I or I11 in the C-1 inhibitor assay and 5 to 30 times more active in suppressing hemolytic activity in undiluted serum. Compound IIb has been shown to potentiate the interaction of C-1 and human serum C-1 inhibitor.* The data of Table I show that it also exerts a lesser inhibitory