Preparation of ethoxycarbonyl isothiocyanate using a pyridine or quinoline catalyst

ME Lewellyn, SS Wang, PJ Strydom

Index: Lewellyn, Morris E.; Wang, Samuel S.; Strydom, Peter J. Journal of Organic Chemistry, 1990 , vol. 55, # 18 p. 5230 - 5231

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Citation Number: 8

Abstract

A process for the preparation of ethoxycarbonyl isothiocyante using pyridine or quinoline as a catalyst in an aqueous medium is presented. This process leads to high yields of the desired product with only trace amounts of the thiocyanate being formed. Reaction of ethoxycarbonyl isothiocyanate, prepared in situ, with nucleophiles can be carried out in with yields and purity.