Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

AA Magda, NI Abdel-Aziz, AM Alaa, AS El-Azab…

Index: El-Sayed, Magda A.-A.; Abdel-Aziz, Naglaa I.; Abdel-Aziz, Alaa A.-M.; El-Azab, Adel S.; Asiri, Yousif A.; Eltahir, Kamal E.H. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 11 p. 3416 - 3424

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Citation Number: 79

Abstract

Abstract New arylhydrazone derivatives and a series of 1, 5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4, 4, 4-trifuorobutane-1, 3-dione 1. The newly synthesized compounds were investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw oedema model. Moreover, they were tested for their inhibitory activity against ovine COX-1 and COX-2 using an in vitro cyclooxygenase (COX) ...