European journal of medicinal chemistry

Potential antineoplastics. Synthesis and cytotoxicity of certain 4-chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives

ESAM Badawey, T Kappe

Index: Badawey; Kappe European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 815 - 822

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Citation Number: 35

Abstract

In an extension of our work in the field of nitrogen heterocycles with potential cytotoxic activity, the synthesis of some substituted 4-chloro-3-(2-chloroethyl)-2-methylquinolines (10– 13) from their parent 3-[1-(phenylamino) ethylioene]-dihybro-2 (3H)-furanomes (6–9) is reported. The conversion of 10–13 to some thieno-, furo-and pyrrolo [3, 2-c] quinotines (14– 27, 31–33) is also described. The compounds were evaluated for their toxicty in brine ...