Chemistry Letters

Total Synthesis of (.+-.)-Aiphanol, a Novel Cyclooxygenase-inhibitory Stilbenolignan

A Kuboki, T Yamamoto, S Ohira

Index: Kuboki, Atsuhito; Yamamoto, Toru; Ohira, Susumu Chemistry Letters, 2003 , vol. 32, # 5 p. 420 - 421

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Citation Number: 19

Abstract

Aiphanol (1), a novel stilbenolignan, which has recently been isolated from the seeds of Aiphanes aculeata Willd (Are- caceae) possesses significant inhibitory activity toward cyclooxygenases-1 and -2.1 Compound 1 demonstrated the IC50 value of 1.9 mM toward cyclooxyganase-1 and of 9.9 mM toward cyclooxyganase-2. Compound 1 has a stilbenolignan skeleton in which a stilbene unit is bridged with a phenylpro- pane moiety by 1,4-dioxane. ...