Bioorganic & medicinal chemistry

Anthracene based base-discriminating fluorescent oligonucleotide probes for SNPs typing: Synthesis and photophysical properties

Y Saito, K Motegi, SS Bag, I Saito

Index: Saito, Yoshio; Motegi, Kaori; Bag, Subhendu Sekhar; Saito, Isao Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 107 - 113

Full Text: HTML

Citation Number: 35

Abstract

2-and 9-Anthracenecarboxamide labeled 2′-deoxyuridines were synthesized and their photophysical properties were examined. These oligonucleonucleotide probes are capable of detecting adenine base on a target DNA sequence. It was also found that 2-anthracene based oligonucleotide probe is more efficient than the corresponding 9-anthracene based oligonucleotide in the application for DNA chip based SNP detection, due to its longer ...