Inhibition of human erythrocyte membrane phosphatidylinositol 4-kinase by phospholipid analogues

RC Young, CP Downes, M Jones, KJ Milliner…

Index: Young; Downes; Jones; Milliner; Rana; Ward European Journal of Medicinal Chemistry, 1994 , vol. 29, # 7-8 p. 537 - 549

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Citation Number: 2

Abstract

Abstract Analogues of phosphatidylinositol (Ptdlns, 1) have been synthesized to investigate the structural requirements for inhibition of a Ptdlns 4-kinase obtained from human erythrocyte membranes. While the presence of either D-1 or D-3 stereochemistry in the inositol moiety greatly influences the degree of inhibition produced by Ptdlns analogues, the stereochemistry of the glycerol moiety is of little consequence. Neither structural feature, ...