Preparation of glycerols protected at the 2-hydroxy-group and their application to the synthesis of lipids

GH Dodd, BT Golding, PV Ioannou

Index: Dodd; Golding; Ioannou Journal of the Chemical Society. Perkin transactions 1, 1976 , # 21 p. 2273 - 2277

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Citation Number: 12

Abstract

IN our synthesis of cardiolipins (1),1 the central glycerol unit was derived from the 2-O-substituted (2a). This precursor was chosen only after examining several possibilities. We provide here full details of the pre- paration of compound (2a), and compare its synthetic utility with that of other new protected glycerols (2b-d). In particular, the attempted application of (2a) to the synthesis of 1,3-diacylglycerols is described. Since we required cardiolipins and 1,3-diacylglycerols ...