Bioorganic & medicinal chemistry letters

Antimicrobial activity of long-chain (E)-3-alken-2-ones

WF Wood, A Kubo, TB Shaffer

Index: Wood, William F.; Kubo, Aya; Shaffer, Tony B. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1819 - 1820

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Citation Number: 2

Abstract

(E)-3-Tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (Odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. Homologues of (E)-3-tridecen-2-one were prepared and screened for antimicrobial activity. For the fungus, Trichophyton mentagrophytes, the minimum inhibitory concentration (MIC) of (E)-3-Tetradecen-2-one was 12.5 μg/mL, and for the bacteria, Propionibacterium ...