Chemoselective one-pot synthesis of β-keto sulfones from ketones
VS Rawat, PLM Reddy, B Sreedhar
Index: Rawat, Vikas S.; Reddy, Perla L. M.; Sreedhar, Bojja RSC Advances, 2014 , vol. 4, # 10 p. 5165 - 5168
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Citation Number: 9
Abstract
A practical method to synthesize substituted β-keto sulfones directly from ketones at room temperature has been developed. This method involves the nucleophilic addition of a base generated enolate to sulfonyl iodide. The reaction shows high chemoselectivity for the addition of a sulfonyl group to an α-carbon over a hydroxyl group. In addition, the given protocol provides good to excellent yields of β-keto sulfones under mild reaction ...
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