Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound

…, B Posteraro, P Vandeputte, D Sanglard…

Index: Sanguinetti, Maurizio; Sanfilippo, Stefania; Castagnolo, Daniele; Sanglard, Dominique; Posteraro, Brunella; Donzellini, Giovanni; Botta, Maurizio ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 9 p. 852 - 857

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Abstract

We recently identified a novel family of macrocyclic amidinoureas showing potent antifungal activity against Candida spp. In this study, we demonstrate the fungicidal effect of these compounds as well as their killing activity in a dose-dependent manner. Transcriptional analysis data indicate that our molecules induce a significant change in the transcriptome involving ABC transporters genes. Notably, experiments against Candida albicans ...