Bioorganic & medicinal chemistry letters

Inhibition of monoamine oxidase by phthalide analogues

B Strydom, JJ Bergh, JP Petzer

Index: Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1269 - 1273

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Citation Number: 11

Abstract

Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory properties of a series of phthalide [2-benzofuran-1 (3H)- one] analogues. Phthalide is structurally related to isatin and phthalimide and it is demonstrated here that substitution at C6 of the phthalide moiety yields compounds ...