A versatile one-pot synthesis of 1, 3-substituted guanidines from carbamoyl isothiocyanates

…, AJ Carr, BP Orner, AD Hamilton

Index: Linton, Brian R.; Carr, Andrew J.; Orner, Brendan P.; Hamilton, Andrew D. Journal of Organic Chemistry, 2000 , vol. 65, # 5 p. 1566 - 1568

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Citation Number: 121

Abstract

Recent advances have demonstrated the importance of the guanidine group in receptors capable of binding molecular anions. 1, 2 The need for more complex receptors required a new protocol for creating highly substituted guanidines under mild conditions. Several new methods have been developed that use carbamate protection to reduce the basicity of guanidines, simplifying purification. 3-8 While these methods permit the mild ...