Quinazolines. 12. 1, 3-Diaminobenzo [f] quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as …

A Rosowsky, PC Huang…

Index: Rosowsky,A. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1217 - 1222

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Citation Number: 11

Abstract

8 9 by its prominent ir absorption at 1740 cm-l. Chemical support for structure 7 was also provided by acid hydrolysis and catalytic hydrogenation, which led successively to 8 (91%) and 9 (92%). The origin of 7 can be rationalized by assuming that the primary adduct, 3-n- heptanoyl-2-methoxynaphthalene, condenses very rapidly with 3-lithio-2- methoxynaphthalene to give an alkoxide which then reacts immediately with another ...