Org. Process Res. Dev

Development of safe, scalable nitric acid oxidation using a catalytic amount of NaNO2 for 3-Bromo-2, 2-bis (bromomethyl) propanoic acid: an intermediate of s-013420

H Osato, M Kabaki, S Shimizu

Index: Osato, Hiroshi; Kabaki, Mikio; Shimizu, Sumio Organic Process Research and Development, 2011 , vol. 15, # 3 p. 581 - 584

Full Text: HTML

Citation Number: 7

Abstract

ABSTRACT: A safe, scalable process was developed for nitric acid oxidation of 3-bromo-2, 2- bis (bromomethyl) propan-1-ol (2) to give 3-bromo-2, 2-bis (bromomethyl) propanoic acid (3), an intermediate in the synthesis of S-013420 (1). The key points are the use of a catalytic amount of NaNO2 and addition of the starting material in portions. We achieved 3,000 L scale pilot production.