Introduction of alkylamino and dialkylamino groups into the quinoline nucleus

NG Luthy, FW Bergstrom…

Index: Luthy et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 1109

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Citation Number: 16

Abstract

It has been shown that quinine is detoxified in the body by oxidation to the 2-hydroxy derivative which has much less therapeutic a~ tivity.~ Since antimalarials containing a quinoline nucleus may suffer a similar fate, the problem of introducing groups into the 2- position in order to block this mode of detoxification was undertaken. It was hoped that amino and substituted alkylamino groups would overcome such objections, and so a ...