Bioorganic & medicinal chemistry letters

Sensitive luciferin derived probes for selective carboxypeptidase activity

YC Chang, PW Chao, CH Tung

Index: Chang, Yu-Cheng; Chao, Pei-Wen; Tung, Ching-Hsuan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 13 p. 3931 - 3934

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Citation Number: 5

Abstract

Abstract Highly selective luminescent probes, QLUC-TYR and LUC-GLU, for detection of carboxypeptidase activity were synthesized. Caged substrates were first cleaved by corresponding carboxypeptidases, and then they were activated by luciferase to emit light. Enzymatic activities of biologically important carboxypeptidases can be determined using this technology.