Synlett

A Straightforward Route to Piloty's Acid Derivatives: A Class of Potential Nitroxyl-Generating Prodrugs

A Porcheddu, L De Luca, G Giacomelli

Index: Porcheddu, Andrea; De Luca, Lidia; Giacomelli, Giampaolo Synlett, 2009 , # 13 p. 2149 - 2153

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Citation Number: 17

Abstract

Abstract A series of Piloty's acid derivatives were easily prepared under mild and neutral conditions. The ease of isolation of the final product offers a marked advantage over well- known procedures. This methodology is particularly attractive as it cleanly provided low molecular weight aliphatic sulfohydroxamic acids, which are very interesting for their tendency to generate HNO under physiological conditions.