The Journal of organic chemistry

The catalytic mannich reaction of 1, 1-difluoro-2-trialkyl (aryl) silyl-2-trimethyl-silyloxyethenes: preparation of β-amino acid derivatives

WJ Chung, M Omote, JT Welch

Index: Higashiya, Seiichiro; Chung, Woo Jin; Lim, Dong Sung; Ngo, Silvana C.; Kelly IV, William H.; Toscano, Paul J.; Welch, John T. Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6323 - 6328

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Citation Number: 29

Abstract

Catalytic Mannich reactions of 1, 1-difluoro-2-trialkyl (aryl) silyl-2-trimethylsilyloxyethenes (3) with a variety of sulfonylimines were utilized for the preparation of α, α-difluoro-β-amino acid derivatives (7). The influence of the Lewis acid on the reaction was examined. Methods for