Et2SBr⋅ SbCl5Br: An Effective Reagent for Direct Bromonium??Induced Polyene Cyclizations

SA Snyder, DS Treitler

Index: Snyder, Scott A.; Treitler, Daniel S. Angewandte Chemie - International Edition, 2009 , vol. 48, # 42 p. 7899 - 7903

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Citation Number: 95

Abstract

Although biomimetic polyene cyclizations [1] have been honed into powerful tools for complex molecule construction in the half-century since the pioneering efforts of Stork and Eschenmoser,[2] several limitations remain. For instance, while nature can deploy heme-or vanadium-based enzymes [3] to enantioselectively fashion an array of natural products, such as 1–3 (Scheme 1),[4] from a broad range of appropriate precursors, such as 4–6,[5] ...

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